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Publications

Peer reviewed publications (in reserve chronological order)
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Jamwal R, Barlock BJ, Adusumalli S, Ogasawara K, Simons BL, Akhlaghi F. Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS. Journal of Proteome Research, 2017 [Epub ahead of print] PMID: 28944677

Cobbina E, Akhlaghi F. Non-alcoholic fatty liver disease (NAFLD) – pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metab Rev. 2017, Mar;1-15. PMID: 28303724.

Jamwal R, Topletz AR, Ramratnam B, Akhlaghi F. Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1048, 10-18. PMID: 28192758.

Lee MR, Scheidweiler KB, Diao XX, Akhlaghi F, Cummins A, Huestis MA, Leggio L, Averbeck BB. Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay. Mol Psychiatry. 2017. [Epub ahead of print] PMID: 28289281.

Haass-Koffler CL, Akhlaghi F, Swift RM, Leggio L. Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks? J Psychopharmacol. 2017. PMID: 28093021.

Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A. Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus. Clin Pharmacokinet. 2016 Nov 10. PMID: 27832452.

Motamedian SR, Tabatabaei FS, Akhlaghi F, Torshabi M, Gholamin P, Khojasteh A. Response of Dental Pulp Stem Cells to Synthetic, Allograft, and Xenograft Bone Scaffolds. Int J Periodontics Restorative Dent. 2016, 37(1):49-59. PMID: 27977818.

Lin S, Henning AK, Akhlaghi F, Reisfield R, Vergara-Silva A, First MR. Interleukin-2 receptor antagonist therapy leads to increased tacrolimus levels after kidney transplantation. Ther Drug Monit. 2015 Apr;37(2):206-13. PMID: 25162212.

Ghareeb M, Leggio L, El-Kattan A, Akhlaghi F. Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain. Anal Bioanal Chem. 2015 Jul;407(19):5603-13.  PMID: 25943263. PMCID: 4499019.

Ghareeb M, Akhlaghi F. Alternative matrices for therapeutic drug monitoring of immunosuppressive agents using LC-MS/MS. Bioanalysis. 2015;7(8):1037-58. PMID: 25966013. PMCID: 4480919.

Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, et al. More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients. Transplantation. 2014 Jun 27;97(12):1266-71. PubMed PMID: 24521776. PMCID: 4127422.

Ionita IA, Ogasawara K, Gohh RY, Akhlaghi F. Pharmacokinetics of total and unbound prednisone and prednisolone in stable kidney transplant recipients with diabetes mellitus. Ther Drug Monit. 2014 Aug;36(4):448-55. PubMed PMID: 24452065. PMCID: 4109138.

Patel CG, Ogasawara K, Akhlaghi F. Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus. Xenobiotica. 2013 Mar;43(3):229-35. PubMed PMID: 22934787. PMCID: 4116557.

Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients. Clin Pharmacokinet. 2013 Sep;52(9):751-62. PubMed PMID: 23633119. PMCID: 3755037.

Mohammadpour AH, Akhlaghi F. Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective. Clin Pharmacokinet. 2013 Aug;52(8):615-26. PubMed PMID: 23658137. PMCID: 3720705.

Dostalek M, Gohh RY, Akhlaghi F. Inosine monophosphate dehydrogenase expression and activity are significantly lower in kidney transplant recipients with diabetes mellitus. Ther Drug Monit. 2013 Jun;35(3):374-83. PubMed PMID: 23666569. PMCID: 4109137.

Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica. 2013 Jul;43(7):641-9. PubMed PMID: 23278282. PMCID: 4116556.

Tsze DS, Steele DW, Machan JT, Akhlaghi F, Linakis JG. Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report. Pediatr Emerg Care. 2012 Aug;28(8):767-70. PubMed PMID: 22858745.

Macwan JS, Ionita IA, Akhlaghi F. A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem. 2012 Jan;402(3):1217-27. PubMed PMID: 22108655.

Longato L, Ripp K, Setshedi M, Dostalek M, Akhlaghi F, Branda M, et al. Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. Oxid Med Cell Longev. 2012;479348. PubMed PMID: 22577490. PMCID: 3347750.

Dostalek M, Sam WJ, Paryani KR, Macwan JS, Gohh RY, Akhlaghi F. Diabetes mellitus reduces the clearance of atorvastatin lactone: results of a population pharmacokinetic analysis in renal transplant recipients and in vitro studies using human liver microsomes. Clin Pharmacokinet. 2012 Sep 1;51(9):591-606. PubMed PMID: 22775412.

Dostalek M, Akhlaghi F, Puzanovova M. Effect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs. Clin Pharmacokinet. 2012 Aug 1;51(8):481-99. PubMed PMID: 22668340.

Akhlaghi F, Dostalek M, Falck P, Mendonza AE, Amundsen R, Gohh RY, et al. The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus. Ther Drug Monit. 2012 Feb;34(1):38-45. PubMed PMID: 22210099.

Macwan JS, Ionita IA, Dostalek M, Akhlaghi F. Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem. 2011 Apr;400(2):423-33. PubMed PMID: 21359569.

Dostalek M, Court MH, Yan B, Akhlaghi F. Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus. Br J Pharmacol. 2011 Jul;163(5):937-47. PubMed PMID: 21323901. PMCID: 3130941.

Dostalek M, Court MH, Hazarika S, Akhlaghi F. Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. PubMed PMID: 21123165. PMCID: 3061563.

Bolin P, Jr., Gohh R, Kandaswamy R, Shihab FS, Wiland A, Akhlaghi F, et al. Mycophenolic acid in kidney transplant patients with diabetes mellitus: does the formulation matter? Transplant Rev (Orlando). 2011 Jul;25(3):117-23. PubMed PMID: 21530217.

Pabla D, Akhlaghi F, Zia H. Intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in MDCK epithelial cell line. Eur J Pharm Sci. 2010 Aug 11;40(5):466-72. PubMed PMID: 20580671.

Narwal R, Akhlaghi F, Asberg A, Hermann M, Rosenbaum SE. Development of a population pharmacokinetic model for atorvastatin acid and its lactone metabolite. Clin Pharmacokinet. 2010 Oct;49(10):693-702. PMID: 20818835.

Ionita IA, Akhlaghi F. Quantification of unbound prednisolone, prednisone, cortisol and cortisone in human plasma by ultrafiltration and direct injection into liquid chromatrography tandem mass spectrometry. Ann Clin Biochem. 2010 Jul;47(Pt 4):350-7. PMID: 20592334.

Hu S, Akhlaghi F, Chitnis S, Chiu R, Go S, Rout P, et al. Comparison of plasma clearance of iodixanol during versus after angiography. Am J Kidney Dis. 2010 Dec;56(6):1219-20. PMID: 21094917.

Dostalek M, Macwan JS, Chitnis SD, Ionita IA, Akhlaghi F. Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1′-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 1;878(19):1629-33. PMID: 20434409.

Akhlaghi F, Gohh RY. The level of ATP production in mitogen-stimulated CD4+ lymphocytes is independent of the time of ingestion of immunosuppressive agents. Ther Drug Monit. 2010 Feb;32(1):116-7. PMID: 20104140.

Teasdale ME, Liu J, Wallace J, Akhlaghi F, Rowley DC. Secondary metabolites produced by the marine bacterium Halobacillus salinus that inhibit quorum sensing-controlled phenotypes in gram-negative bacteria. Appl Environ Microbiol. 2009 Feb;75(3):567-72. PMID: 19060172. PMCID: 2632121.

Sam WJ, Akhlaghi F, Rosenbaum SE. Population pharmacokinetics of mycophenolic acid and its 2 glucuronidated metabolites in kidney transplant recipients. J Clin Pharmacol. 2009 Feb;49(2):185-95. PMID: 19179297.

Pabla D, Akhlaghi F, Zia H. A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry. Eur J Pharm Biopharm. 2009 May;72(1):105-10. PMID: 18996189.

Ionita IA, Fast DM, Akhlaghi F. Development of a sensitive and selective method for the quantitative analysis of cortisol, cortisone, prednisolone and prednisone in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 15;877(8-9):765-72. PMID: 19237320.

Pabla D, Akhlaghi F, Ahmed A, Zia H. Development and validation of an inductively coupled plasma mass spectrometry method for quantification of levothyroxine in dissolution studies. Rapid Commun Mass Spectrom. 2008 Apr;22(7):993-6. PMID: 18320549.

Mendonza AE, Gohh RY, Akhlaghi F. Blood and plasma pharmacokinetics of ciclosporin in diabetic kidney transplant recipients. Clin Pharmacokinet. 2008;47(11):733-42. PMID: 18840028.

Falck P, Asberg A, Guldseth H, Bremer S, Akhlaghi F, Reubsaet JL, et al. Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients. Transplantation. 2008 Jan 27;85(2):179-84. PMID: 18212621.

Chitnis SD, Akhlaghi F. Development and validation of an HPLC-UV method for iodixanol quantification in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 15;869(1-2):133-7. PubMed PMID: 18502708.

Plante T, Harris D, Savitt J, Akhlaghi F, Monti J, Jay GD. Carboxyhemoglobin monitored by bedside continuous CO-oximetry. J Trauma. 2007 Nov;63(5):1187-90. PubMed PMID: 17993970.

Patel CG, Richman K, Yang D, Yan B, Gohh RY, Akhlaghi F. Effect of diabetes mellitus on mycophenolate sodium pharmacokinetics and inosine monophosphate dehydrogenase activity in stable kidney transplant recipients. Ther Drug Monit. 2007 Dec;29(6):735-42. PubMed PMID: 18043470. PMCID: 4082794.

Patel CG, Harmon M, Gohh RY, Akhlaghi F. Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus. Ther Drug Monit. 2007 Feb;29(1):87-95. PubMed PMID: 17304155.

Mendonza AE, Zahir H, Gohh RY, Akhlaghi F. Tacrolimus in diabetic kidney transplant recipients: pharmacokinetics and application of a limited sampling strategy. Ther Drug Monit. 2007 Aug;29(4):391-8. PubMed PMID: 17667791.

Zahir H, Keogh AM, Akhlaghi F. Apparent clearance of sirolimus in heart transplant recipients: impact of primary diagnosis and serum lipids. Ther Drug Monit. 2006 Oct;28(5):614-22. PubMed PMID: 17038875.

Zahir H, Keogh A, Akhlaghi F. Apparent clearance of sirolimus in heart transplant recipients: impact of primary diagnosis and serum lipids. Ther Drug Monit. 2006 Dec;28(6):818-26. PubMed PMID: 17203553.

Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, et al. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 2006 Dec;319(3):1477-84. PubMed PMID: 16966469.

Patel CG, Akhlaghi F. High-performance liquid chromatography method for the determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human plasma. Ther Drug Monit. 2006 Feb;28(1):116-22. PubMed PMID: 16418705.

Mendonza AE, Gohh RY, Akhlaghi F. Analysis of mycophenolic acid in saliva using liquid chromatography tandem mass spectrometry. Ther Drug Monit. 2006 Jun;28(3):402-6. PubMed PMID: 16778726.

Akhlaghi F, Patel CG, Zuniga XP, Halilovic J, Preis IS, Gohh RY. Pharmacokinetics of mycophenolic acid and metabolites in diabetic kidney transplant recipients. Ther Drug Monit. 2006 Feb;28(1):95-101. PubMed PMID: 16418701.

Zahir H, McLachlan AJ, Nelson A, McCaughan G, Gleeson M, Akhlaghi F. Population pharmacokinetic estimation of tacrolimus apparent clearance in adult liver transplant recipients. Ther Drug Monit. 2005 Aug;27(4):422-30. PubMed PMID: 16044097.

Soman RS, Zahir H, Akhlaghi F. Development and validation of an HPLC-UV method for determination of iohexol in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):339-43. PubMed PMID: 15664368.

Rosenbaum SE, Baheti G, Trull AK, Akhlaghi F. Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients. Ther Drug Monit. 2005 Apr;27(2):116-22. PubMed PMID: 15795639.

Akhlaghi F, Gonzalez L, Trull AK. Association between cyclosporine concentrations at 2 hours post-dose and clinical outcomes in de novo lung transplant recipients. J Heart Lung Transplant. 2005 Dec;24(12):2120-8. PubMed PMID: 16364860.

Trull AK, Akhlaghi F, Charman SC, Endenberg S, Majid O, Cornelissen J, et al. Immunosuppression, eotaxin and the diagnostic changes in eosinophils that precede early acute heart allograft rejection. Transpl Immunol. 2004 Jan;12(2):159-66. PubMed PMID: 14967314.

Patel CG, Mendonza AE, Akhlaghi F, Majid O, Trull AK, Lee T, et al. Determination of total mycophenolic acid and its glucuronide metabolite using liquid chromatography with ultraviolet detection and unbound mycophenolic acid using tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):287-94. PubMed PMID: 15556544.

Mendonza A, Gohh R, Akhlaghi F. Determination of cyclosporine in saliva using liquid chromatography-tandem mass spectrometry. Ther Drug Monit. 2004 Oct;26(5):569-75. PubMed PMID: 15385841.

Ray JE, Keogh AM, McLachlan AJ, Akhlaghi F. Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors. J Heart Lung Transplant. 2003 Jul;22(7):715-22. PubMed PMID: 12873538.

Akhlaghi F, Trull AK. Distribution of cyclosporin in organ transplant recipients. Clin Pharmacokinet. 2002;41(9):615-37. PubMed PMID: 12126456.

Akhlaghi F, Jackson CH, Parameshwar J, Sharples LD, Trull AK. Risk factors for the development and progression of dyslipidemia after heart transplantation. Transplantation. 2002 Apr 27;73(8):1258-64. PubMed PMID: 11981418.

Trull AK, Charman SC, Endenburg S, Akhlaghi F, Majid O, Cornelissen J, et al. Eotaxin and prednisolone concentrations regulate the mobilisation of peripheral blood eosinophils preceding heart allograft rejection. J Heart Lung Transplant. 2001 Feb;20(2):161. PubMed PMID: 11250241.

Majid O, Akhlaghi F, Lee T, Holt DW, Trull A. Simultaneous determination of plasma prednisolone, prednisone, and cortisol levels by high-performance liquid chromatography. Ther Drug Monit. 2001 Apr;23(2):163-8. PubMed PMID: 11294518.

Akhlaghi F, Keogh AM, McLachlan AJ, Kaan A. Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors. J Heart Lung Transplant. 2001 Apr;20(4):431-8. PubMed PMID: 11295581.

Trull AK, Steel LA, Sharples LD, Akhlaghi F, Parameshwar J, Cary N, et al. Randomized trial of blood eosinophil count monitoring as a guide to corticosteroid dosage adjustment after heart transplantation. Transplantation. 2000 Sep 15;70(5):802-9. PubMed PMID: 11003362.

Akhlaghi F, Keogh AM, Brown KF. Unbound cyclosporine and allograft rejection after heart transplantation. Transplantation. 1999 Jan 15;67(1):54-9. PubMed PMID: 9921795.

Akhlaghi F, Ashley J, Keogh A, Brown K. Cyclosporine plasma unbound fraction in heart and lung transplantation recipients. Ther Drug Monit. 1999 Feb;21(1):8-16. PubMed PMID: 10051049.

Akhlaghi F, Ashley JJ, Keogh AM, Brown KF. Indirect estimation of the unbound fraction of cyclosporine in plasma. Ther Drug Monit. 1998 Jun;20(3):301-8. PubMed PMID: 9631927.

Akhlaghi F, McLachlan AJ, Keogh AM, Brown KF. Effect of simvastatin on cyclosporine unbound fraction and apparent blood clearance in heart transplant recipients. Br J Clin Pharmacol. 1997 Dec;44(6):537-42. PubMed PMID: 9431828. PMCID: 2042891.