The laboratory specializes on the effect of disease states on drug development, drug disposition, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and therapeutic drug monitoring (TDM). Located in the College of Pharmacy at the Kingston Campus of the University of Rhode Island, the laboratory is equipped with cutting edge analytical equipments including an AB Sciex 3200 LC-MS/MS, a Xevo™ TripleQuad LC-MS/MS, an AB Sciex 5600 LC-Tandem TOF/MSn, High Performance Liquid Chromatography (HPLC-UV, Hitachi) and a MAGPIX® multiplex unit. A wide range of other instruments are also accesible to laboratory personnel through RI-INBRE centralized core facility located in the College of Pharmacy. In addition, our lab has access to and expertise on the use of a number of in-silico tools like Simcyp, ADMET predictor, WinNonlin®, and NONMEM.
The Principal Investigator is Fatemeh Akhlaghi, PharmD, PhD, Professor & Ernest Mario Distinguished Chair in Pharmaceutics. The lab is located in Lab Module 490 on Level 4 of the Pharmacy building. We have established and validated different analytical methods for determination of immunosuppressive agents (i.e. cyclosporine, tacrolimus, sirolimus and mycophenolic acid) and other medications in different matrices (plasma, serum, brain, saliva). In addition, we specialize in the measurement of free (unbound) drug concentration, either in plasma or oral fluids (saliva), and have established methods for determination of contrast media agents, iohexol or iodixanol, useful for accurate estimation of Glomerular Filtration Rate (GFR).
The current focus of lab is on development of a treatment for alcoholism by translational approach and also to evaluate the effect of different disease conditions (diabetes, NASH and alcoholism) on the drug metabolism enzymes and transporters.